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How can I facilitate sharing large amounts of data between myself and my co-PI, who's located across the country?

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There are various options for facilitating data sharing across disparate locations. The following requirements should be investigated: risk associated with the data (sensitive data, HIPAA, IRB, commercial data), institutional resources available to you, file size, upload/download speed needs, is versioning necessary, and levels of access (if opening to other contributors). With these considerations in mind, I would recommend that you reach out to your institutional IT group and see if they have any resources available to you.